• Ecyrus Leconte, 1852
• Eipperus Hoser, 2012 accepted as Psammophis Fitzinger, 1826
• Ekorus Werdelin, 2003 †
• Emerus O. Kuntze, 1891 (unaccepted)
• Emerus P. Miller, 1754 accepted as Hippocrepis Linnaeus, 1753
• Empeirus Motschoulsky, 1844 accepted as Harpalus Latreille, 1802
• Endrus Uchida, 1936 (unaccepted)
• Eocerus Schlosser in Zittel, 1911 † accepted as Eotragus Pilgrim, 1939 † [Family: Bovidae]
• Eocerus Sharp, 1907 [Family: Dermestidae]
• Eogrus Wetmore, 1934 †
• Eoxerus Major, 1893 † (uncertain)
• Epelis Hulst, 1896
• Epelys Dana, 1849 accepted as Edotia Guérin-Méneville, 1843
• Epeolus Latreille, 1802
• Epeorus Eaton, 1881
• Eperia Robineau-Desvoidy, 1863 (uncertain > nomen dubium)
• Eperua Aublet, 1775
• Epeus Godman, 1901 accepted as Eprius Godman, 1901 [Family: Hesperiidae]
• Epeus Kuwert, 1896 accepted as Pentalobus Kaup in Harold, 1868 [Family: Passalidae]
• Epeus Peckham, 1885 [Family: Salticidae]
• Ephedrus Haliday, 1833
• Ephyrus Lea, 1913 accepted as Ephrycus Pascoe, 1870
• Epicerus Laporte (uncertain)
• Epierus Erichson, 1834
• Epigrus Hedley, 1903
• Epirus Zimmerman, 1994
• Epiurus Förster, 1868 (uncertain) [Family: Hymenoptera (awaiting allocation)]
• Epiurus Rafinesque, 1815 (unaccepted > nomen nudum) [Family: Oligochaeta (awaiting allocation)]
• Epixerus Thomas, 1909
• Eporus Grouvelle, 1897
• Epyris Westwood, 1832 (uncertain)
• Estrus Lioy, 1865 accepted as Oestrus Linnaeus, 1758
• Eucerus Verhoeff, 1892 accepted as Euceros Gravenhorst, 1829
• Euderus Haliday, 1844
• Eumerus Champion, 1911 (uncertain) [Family: Curculionidae]
• Eumerus Geoffroy, 1829 accepted as Macroscelides Smith, 1829 [Family: Macroscelididae]
• Eumerus Klug in Ehrenberg, 1830 (uncertain) [Family: Hemiptera (awaiting allocation)]
• Eumerus Laporte & Gory, 1839 accepted as Euamyia Kerremans, 1903 [Family: Buprestidae]
• Eumerus Meigen, 1804 [Family: Syrphidae]
• Euporus Audinet-Serville, 1834
• Eupterus Fiedler, 1941 accepted as Cryptorhynchus Illiger, 1807
• Eupterus Jekel, 1873 accepted as Metrania Pascoe, 1872
• Euterus Ishii, 1938 (unaccepted)
• Euxerus Thomas, 1909 accepted as Xerus Ehrenberg, 1833
• Exedrus Raffray, 1903
• Exeirus Shuckard, 1838
• Exurus Philippi, 1873
• Perus Grishin, 2019