• Polygala Linnaeus, 1753
• Polygala aboriginum Small accepted as Polygala polygama Walt.
• Polygala acanthoclada Gray
• Polygala alba Nutt.
• Polygala ambigua Nutt.
• Polygala arenicola Small accepted as Polygala smallii R.R. Sm. & Ward
• Polygala balduinii Nutt.
• Polygala barbeyana Chod.
• Polygala boykinii Nutt.
• Polygala brevifolia Nutt.
• Polygala brizoides St.-Hil. accepted as Polygala violacea Aubl.
• Polygala californica Nutt.
• Polygala chapmanii Torr. & Gray
• Polygala corallicola Small accepted as Polygala grandiflora Walt.
• Polygala cornuta Kellogg
• Polygala cowellii (Britt.) Blake
• Polygala crenata C.W. James
• Polygala crotalarioides Buch.-Ham. ex DC.
• Polygala crucianelloides DC.
• Polygala cruciata Linnaeus
• Polygala cumulicola Small accepted as Polygala grandiflora Walt.
• Polygala curtissii Gray
• Polygala cymosa Walt.
• Polygala eucosma S.F. Blake
• Polygala fishiae Parry accepted as Polygala cornuta Kellogg
• Polygala flagellaris Small accepted as Polygala boykinii Nutt.
• Polygala glandulosa Kunth
• Polygala glochidiata Kunth
• Polygala grandiflora Walt.
• Polygala harperi Small accepted as Polygala mariana P. Mill.
• Polygala hecatantha Urban
• Polygala hemipterocarpa Gray
• Polygala heterorhyncha (Barneby) T. Wendt
• Polygala hookeri Torr. & Gray
• Polygala incarnata Linnaeus
• Polygala intermontana T. Wendt
• Polygala leptocaulis Torr. & Gray
• Polygala leptostachys Shuttlw. ex Gray
• Polygala lewtonii Small
• Polygala lindheimeri Gray
• Polygala longa Blake accepted as Polygala barbeyana Chod.
• Polygala longicaulis Kunth
• Polygala lutea Linnaeus
• Polygala macradenia Gray
• Polygala maravillasensis Correll
• Polygala mariana P. Mill.
• Polygala miamiensis Small ex Blake accepted as Polygala grandiflora Walt.
• Polygala minutifolia auct. non Rose accepted as Polygala nudata Brandeg.
• Polygala monticola H.B.K.
• Polygala myrtifolia Linnaeus
• Polygala nana (Michx.) DC.
• Polygala nitida Brandeg.
• Polygala northropiana R.N. Banerjee accepted as Polygala boykinii Nutt.
• Polygala nudata Brandeg.
• Polygala nuttallii Torr. & Gray
• Polygala obscura Benth.
• Polygala orthotricha Blake accepted as Polygala obscura Benth.
• Polygala ovatifolia Gray
• Polygala palmeri S. Wats.
• Polygala paniculata Linnaeus
• Polygala paucifolia Willd.
• Polygala penaea Linnaeus
• Polygala piliophora Blake
• Polygala planellasii Molinet & Maz
• Polygala polygama Walt.
• Polygala portoricensis (Britt.) Blake accepted as Polygala penaea Linnaeus
• Polygala praetervisa Chod. accepted as Polygala boykinii Nutt.
• Polygala pretzii Pennell accepted as Polygala verticillata Linnaeus
• Polygala racemosa Blake accepted as Polygala barbeyana Chod.
• Polygala ramosa Ell.
• Polygala ramosior (Nash) Small accepted as Polygala cruciata Linnaeus
• Polygala rectipilis Blake
• Polygala rectipilus Blake
• Polygala reducta Blake accepted as Polygala barbeyana Chod.
• Polygala rimulicola Steyermark
• Polygala rugelii Shuttlw. ex Chapman
• Polygala rusbyi Greene
• Polygala sanguinea Linnaeus
• Polygala scoparioides Chod.
• Polygala senega Linnaeus
• Polygala serpyllifolia J.A. Hose
• Polygala setacea Michx.
• Polygala smallii R.R. Sm. & Ward
• Polygala subspinosa S. Wats.
• Polygala tenuiloba Blake
• Polygala tweedyi Britt. ex Wheelock accepted as Polygala lindheimeri Gray
• Polygala verticillata Linnaeus
• Polygala violacea Aubl.
• Polygala viridescens Linnaeus accepted as Polygala sanguinea Linnaeus
• Polygala vulgaris Linnaeus
• Polygala watsoni Chodat
• Polygala watsonii Chod.
• Polygalaceae Hoffmannsegg & Link, 1809
• Polygalacidites S.C.D. Sah & S.K. Dutta, 1966 †
• Polygalales accepted as Fabales