• Protomolis Hampson, 1901 (uncertain)
• Protopalsis Osborn, 1900 † (unaccepted)
• Protopalus Schönherr, 1837 accepted as Hypsophorus Dejean, 1835
• Protopeltis Crowson, 1964 [Family: Protopeltidae]
• Protopeltis H. Sydow, 1927 accepted as Myriangiella A. Zimmermann, 1902 [Family: Schizothyriaceae]
• Protophallus Murrill, 1910 accepted as Protubera A. Møller, 1895
• Protopolia Varga, Ronkay & Ronkay, 2017 accepted as Polia Ochsenheimer, 1816
• Protopsalis Cope, 1880 † accepted as Patriofelis Leidy, 1870 †