• Sabatia Adanson, 1763 [Family: Gentianaceae]
• Sabatia Bellardi, 1877 [Family: Scaphandridae]
• Sacatia Walker, 1863 (uncertain)
• Sagotia Baillon, 1860 [Family: Euphorbiaceae]
• Sagotia Duchassaing & Walpers, 1851 (unaccepted) [Family: Fabaceae]
• Saintia Raincourt, 1877 †
• Salentia Costa, 1857 [Family: Therevidae]
• Salentia Gray, 1840 accepted as Salenia Gray, 1835 [Family: Saleniidae]
• Saltia Malaise, 1955 (uncertain) [Family: Tenthredinidae]
• Saltia R. Brown ex Moquin in Alph. de Candolle, 1849 [Family: Amaranthaceae]
• Saltia Tams, 1952 [Family: Noctuidae]
• Santia † (unaccepted) [Family: Sacoglossa (awaiting allocation)]
• Santia R. Wight & Arnott, 1834 accepted as Lasianthus W. Jack, 1823 [Family: Rubiaceae]
• Santia Savi, 1799 accepted as Polypogon Desfontaines, 1798 [Family: Poaceae]
• Santia Sivertsen & Holthuis, 1980 [Family: Santiidae]
• Saphtia de Winter, 2008
• Sapitia Achard, 1920
• Saugetia Hitchcock & Chase, 1917 accepted as Enteropogon C.G.D. Nees in Lindley, 1836
• Saxella Morgan, 1896 (uncertain)
• Saxetania Mishchenko, 1951
• Saxonia G. Roselt, 1962 † (uncertain)
• Segetia Stephens, 1829 (uncertain)
• Senetia Kraglievich, 1927 (uncertain)
• Siretia Pallary, 1926 (uncertain)
• Sketia Hadzi, 1973 accepted as Holoscotolemon Roewer, 1915
• Sloetia Teysmann & Binnendijk ex Kurz, 1864 accepted as Streblus Loureiro, 1790
• Sometia Meigen, 1829 accepted as Sesia Fabricius, 1775
• Sudetia Rózkowska, 1960 †
• Svanetia Hesse, 1926 (uncertain) [Family: Mollusca (awaiting allocation)]
• Svanetia Shengeliya & Dlabola, 1964 (uncertain) [Family: Hemiptera (awaiting allocation)]
• Sweetia A.P. de Candolle, 1825 (unaccepted)
• Sweetia K.P.J. Sprengel, 1825