• Rhinus Martens, 1860 [Family: Simpulopsidae]
• Rhinus Pierce, 1916 accepted as Rhinostomus Rafinesque, 1815 [Family: Dryophthoridae]
• Sakinus Rafinesque, 1815 (uncertain)
• Sarnus Stål, 1866 (uncertain)
• Schinus Linnaeus, 1753
• Scimnus Wood, 1837 accepted as Dalatias Rafinesque, 1810
• Scinus Steindachner, 1867 accepted as Scincus Laurenti, 1768
• Selinus Mulsant & Rey, 1853
• Semnus Lacordaire, 1869 accepted as Ancylodonta Blanchard, 1851
• Serinus Brisson, 1760 [Family: Fringillidae]
• Serinus Jarocki, 1822 (uncertain) [Family: Pisces (awaiting allocation)]
• Serinus Preston, 1912 (unaccepted) [Family: Mollusca (awaiting allocation)]
• Shanus Tanasevitch, 2006
• Shenius Serène, 1971
• Sicinus Champion, 1886 accepted as Gnatocerus Thunberg, 1814
• Silinus Lewis, 1907
• Sineus Deslongchamps, 1827 accepted as Lineus Sowerby, 1806
• Sohenus Distant, 1910 (uncertain)
• Solinus Chamberlin, 1931
• Spanus Westwood, 1864 accepted as Pelecium Kirby, 1819
• Sphenus Desbrochers, 1906 accepted as Homalinotus Schönherr in Sahlberg, 1823
• Spinus Guichenot in Gay, 1849 accepted as Etmopterus Rafinesque, 1810 [Family: Etmopteridae]
• Spinus Hong, 1982 † (uncertain) [Family: Hemiptera (awaiting allocation)]
• Spinus Koch, 1816 accepted as Carduelis Brisson, 1760 [Family: Fringillidae]
• Spinus Möhring, 1758 accepted as Carduelis Brisson, 1760 [Family: Fringillidae]
• Stanus Ślipiński, Tomaszewska & Lawrence, 2009
• Stenus Latreille, 1796
• Stimnus Rafinesque, 1814 (uncertain)
• Stinus Sellards, 1909 † (uncertain)
• Sunius Erichson, 1839 accepted as Astenus Dejean, 1833
• Sunius Stephens, 1829
• Sunius Stephens, 1833
• Syrinus Erichson, 1841 accepted as Saprinus Erichson, 1834
• Sysinus Kirkaldy, 1902 accepted as Sysinas Distant, 1883