• Sinuina Jung, 1989
• Sinusina Stepanaitys, 1988 †
• Siphulina (Hue) C.W. Dodge, 1965
• Spatulina Osmólska, 1962 † [Family: Proetidae]
• Spatulina Szilády, 1942 [Family: Spaniidae]
• Speculina Whalley, 1976
• Spinalia Santos & Ribeiro, 2018 accepted as Aphrophila Edwards, 1923 [Family: Limoniidae]
• Spinalia Vuillemin, 1904 [Family: Dimargaritales incertae sedis]
• Spinalona Ciros-Perez & Elias-Gutierrez, 1997 (uncertain)
• Spinellina Melnikova, 1976 † (uncertain)
• Spinigina Dietrich & Dmitriev, 2006
• Spinolia A. Costa in O. Costa, 1858 (uncertain) [Family: Mutillidae]
• Spinolia Dahlbom, 1854 (uncertain) [Family: Chrysididae]
• Spinolia Förster, 1868 (uncertain) [Family: Ichneumonidae]
• Spinolia Robineau-Desvoidy, 1863 accepted as Blondelia Robineau-Desvoidy, 1830 [Family: Tachinidae]
• Spinoliva G. Sancho, F. Luebert & L. Katinas in Sancho et al., 2018
• Spinovina Coryell & Malkin, 1936 †
• Spinula Dall, 1908 accepted as Acutispinula Filatova & Schileyko, 1984 accepted as Bathyspinula Allen & Sanders, 1982 [Family: Bathyspinulidae]
• Spinula Herrich-Schäffer, 1856 (uncertain) [Family: Lepidoptera (awaiting allocation)]
• Spinula Woodring, 1925 † accepted as Spisula Gray, 1837 [Family: Mactridae]
• Spinulana DeLong, 1967
• Spinulata Davis, Gentili-Poole & Mitter, 2008
• Spinuncina Wehrli, 1937 (uncertain)
• Spiralina Chaster, 1898 accepted as Spiralinella Chaster, 1901 [Family: Pyramidellidae]
• Spiralina Hartmann, 1840 (uncertain) [Family: Bryozoa (awaiting allocation)]
• Spiralina Martens, 1899 accepted as Anisus Studer, 1820 [Family: Planorbidae]
• Spirilina Bory de St. Vincent, 1826 (uncertain)
• Spirolina Lamarck, 1804
• Spirulina Bory, 1826 (unaccepted) [Class: Protozoa (awaiting allocation)]
• Spirulina Turpin ex Gomont, 1892 [Class: Cyanophyceae]
• Spisulina P. Fischer, 1887 accepted as Spisula Gray, 1837
• Spisulona Marwick, 1948 † accepted as Spisula Gray, 1837
• Stipulina Lys & Marcoux, 1978 † accepted as Rectostipulina Jenny-Deshusses, 1985 † [Family: Syzraniidae]
• Stipulina Muir-Wood & Cooper, 1960 † [Family: Aulostegidae]