• Mesothuria abbreviata Koehler & Vaney, 1905
• Mesothuria aculeata (O'Loughlin)
• Mesothuria bifurcata Hérouard, 1901
• Mesothuria candelabra Hérouard, 1923
• Mesothuria candelabri Hérouard, 1923
• Mesothuria carnosa Fisher, 1907
• Mesothuria cathedralis Heding, 1940
• Mesothuria connectens (R. Perrier, 1898)
• Mesothuria crebrapedes Cherbonnier & Féral, 1981
• Mesothuria deani Mitsukuri, 1912 accepted as Mesothuria parva (Théel, 1886)
• Mesothuria edwardensis Massin, 1992
• Mesothuria expectans Perrier R, 1899
• Mesothuria gargantua Deichmann, 1930
• Mesothuria hokutenica Imaoka, 1990
• Mesothuria holothurioides Sluiter, 1901
• Mesothuria incerta Koehler & Vaney, 1905
• Mesothuria intestinalis (Ascanius, 1805)
• Mesothuria lactea (Théel, 1886) accepted as Zygothuria lactea (Théel, 1886)
• Mesothuria magellani Ludwig, 1883
• Mesothuria marginata Sluiter, 1901
• Mesothuria maroccana Perrier R, 1898
• Mesothuria media Ohshima, 1915
• Mesothuria megapoda Clark, 1920
• Mesothuria milleri Gebruk & Solis-Marin in Gebruk et al., 2011
• Mesothuria multipes Ludwig, 1893
• Mesothuria multipora Clark, 1920
• Mesothuria murrayi Théel, 1886
• Mesothuria norfolkensis Rowe, 1989
• Mesothuria oktaknemoides Heding, 1940
• Mesothuria oktaknemus Sluiter, 1901 accepted as Mesothuria verrilli (Théel, 1886)
• Mesothuria parva (Théel, 1886)
• Mesothuria regularia Heding, 1940
• Mesothuria roulei (Koehler, 1896)
• Mesothuria rugosa Hérouard, 1912
• Mesothuria squamosa Koehler & Vaney, 1905
• Mesothuria sufflava Cherbonnier & Féral, 1984
• Mesothuria thomsoni (Théel, 1886)
• Mesothuria triradiata Heding, 1942
• Mesothuria verrilli (Théel, 1886)
• Zygothuria connectens Perrier R, 1898 accepted as Mesothuria connectens (R. Perrier, 1898)
• Zygothuria lactea (Théel, 1886)
• Zygothuria oxysclera (Perrier R, 1902)
• Zygothuria thomsoni (Théel, 1886)