Acanthogobius Gill, 1859 (original description)
Adinia Girard, 1859 (original description)
Alethe Cassin, 1859 (original description)
Alvarius Girard, 1859 accepted as Gobiomorus Lacepède, 1800 (original description)
Alvordius Girard, 1859 accepted as Percina Haldeman, 1842 (original description)
Amydria Clemens, 1859 (original description)
Anaphora Clemens, 1859 (original description)
Antocha Osten-Sacken, 1859 (original description)
Arlina Girard, 1859 accepted as Etheostoma Rafinesque, 1819 (original description)
Boleichthys Girard, 1859 accepted as Etheostoma Rafinesque, 1819 (original description)
Boreocottus Gill, 1859 accepted as Myoxocephalus Tilesius, 1811 (original description)
Calloselasma Cope, 1859 (original description)
Camarataxis Cope, 1859 (original description)
Ceratocottus Gill, 1859 accepted as Enophrys Swainson, 1839 (original description)
Cryptelytrops Cope, 1859 (original description)
Dactylolabis Osten-Sacken, 1859 (original description)
Dactylopus Gill, 1859 (original description)
Dactyloscopus Gill, 1859 (original description)
Dicranophragma Osten-Sacken, 1859 (original description)
Entomacrodus Gill, 1859 (original description)
Epiphragma Osten-Sacken, 1859 (original description)
Estrella Girard, 1859 accepted as Etheostoma Rafinesque, 1819 (original description)
Euleptorhamphus Gill, 1859 (original description)
Euprinodes Cassin, 1859 (original description)
Eurydorus Leidy, 1859 (original description)
Evorthodus Gill, 1859 (original description)
Glossogobius Gill, 1859 (original description)
Heptathyra Cope, 1859 (original description)
Hylia Cassin, 1859 (original description)
Hypodes Cassin, 1859 (original description)
Hyporhamphus Gill, 1859 (original description)
Lasiomastix Osten-Sacken, 1859 (original description)
Leptoscopus Gill, 1859 (original description)
Leucanthiza Clemens, 1859 (original description)
Lucania Girard, 1859 (original description)
Luciogobius Gill, 1859 (original description)
Macrosphenus Cassin, 1859 (original description)
Myrichthys Girard, 1859 (original description)
Oligocephalus Girard, 1859 accepted as Etheostoma Rafinesque, 1819 (original description)
Olisthenes Cope, 1859 (original description)
Ontocetus Leidy, 1859 † (original description)
Parmoptila Cassin, 1859 (original description)
Pimeletropis Gill, 1859 accepted as Calophysus Müller & Troschel in Müller, 1843 (original description)
Porocottus Gill, 1859 (original description)
Prionolabis Osten-Sacken, 1859 (original description)
Pterognathus Girard, 1859 (original description)
Pyrrhurus Cassin, 1859 (original description)
Rhinogobius Gill, 1859 (original description)
Synchiropus Gill, 1859 (original description)
Teleuraspis Cope, 1859 (original description)
Triaenophorichthys Gill, 1859 accepted as Tridentiger Gill, 1859 (original description)
Typhlichthys Girard, 1859 (original description)
Xylesthia Clemens, 1859 (original description)
Xystracanthus Leidy, 1859 (original description)